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Siglec-3/CD33 Products

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: Siglecs-1, -2, and -4, and a Siglec-3/CD33-related subgroup (Siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and Siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.

68 results for "Siglec-3/CD33" in Products

Siglec-3/CD33 Products

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: Siglecs-1, -2, and -4, and a Siglec-3/CD33-related subgroup (Siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and Siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.

68 results for "Siglec-3/CD33" in Products

Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies

Flow, CyTOF-ready

Recombinant Monoclonal Antibody For Research Use Only

WB
WB, IHC, ICC
Flow

Recombinant Monoclonal Antibody For Research Use Only

Flow

Recombinant Monoclonal Antibody. Bivalent Llama VHH domain, Llama IgG2 Fusion Antibody.

Catalog #: FAB11373S
Flow

Recombinant Monoclonal Antibody.

WB, Flow, CyTOF-ready
BA

Fc Chimera

BA

Fc Chimera

BA
BA

Biotinylated

BA
BA
Catalog #: AF2220
WB
BA
Catalog #: FAB9635U
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB9635N
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB9635R
Flow

Recombinant Monoclonal Antibody For Research Use Only

Flow, CyTOF-ready

Recombinant Monoclonal Antibody.

Catalog #: FAB11373G
Flow

Recombinant Monoclonal Antibody.

Catalog #: FAB9635V
Flow

Recombinant Monoclonal Antibody For Research Use Only

BA
BA
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