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Siglec-3/CD33 Products

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: Siglecs-1, -2, and -4, and a Siglec-3/CD33-related subgroup (Siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and Siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.

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392 results for "Siglec-3/CD33" in Products

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Siglec-3/CD33 Products

Siglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: Siglecs-1, -2, and -4, and a Siglec-3/CD33-related subgroup (Siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and Siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although Siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.

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392 results for "Siglec-3/CD33" in Products

WB, ELISA
ELISA
WB, Flow, CyTOF-ready
BA

Fc Chimera

Flow, CyTOF-ready

Recombinant Monoclonal Antibody For Research Use Only

Flow
BA
Flow, ICC

Recombinant Monoclonal Antibody. His-tagged VHH domain.

BA, BA
Flow, ICC

Recombinant Monoclonal Antibody. His-tagged VHH domain.

BA
BA
Flow

Recombinant Monoclonal Antibody For Research Use Only

Catalog #: FAB1137T
Flow
IHC, WB, ELISA, Flow
Flow, CyTOF-ready

Recombinant Monoclonal Antibody.

BA, BA

Biotinylated

Flow, ICC

Recombinant Monoclonal Antibody. His-tagged VHH domain.

Flow, ICC

Recombinant Monoclonal Antibody. His-tagged VHH domain.

Catalog #: FAB1137S
Flow
Flow

Recombinant Monoclonal Antibody For Research Use Only

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