RIG-I Products

RIG-I-like Receptors (RLRs) are a subset of cytosolic pattern recognition receptors that are essential for antiviral immunity. The RLR family consists of three members: RIG-I, MDA5, and LGP2. Unlike the NOD-like Receptor (NLR) family proteins, the RLR proteins are RNA helicases that recognize viral RNA. RIG-I and MDA5 contain two N-terminal caspase recruitment domains (CARDs), an internal RNA helicase domain, and a C-terminal repressor/RNA-binding domain. Signaling through both receptors ...