Plexin B3: Proteins and Enzymes

Plexin B3 is a 260 kDa type I transmembrane glycoprotein in the Plexin B subfamily of semaphorin receptors. Its identified ligand is the transmembrane semaphorin Sema5A, and are both expressed during differentiation and migration of central nervous system oligodendrocytes. Plexin B3 can interact with the transmembrane scatter factor receptors Met and Ron, activating these receptors and the signaling molecule RhoA upon semaphorin engagement. This signaling can mediate axonal growth cone collapse.

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