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PD-L2/B7-DC: Antibodies

PD-L2 (Programmed Death Ligand 2), also known as B7-DC and butyrophilin-like protein, is a transmembrane protein expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites, PD-L2 is upregulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand upregulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.

33 results for "PD-L2/B7-DC Primary Antibodies" in Products

PD-L2/B7-DC: Antibodies

PD-L2 (Programmed Death Ligand 2), also known as B7-DC and butyrophilin-like protein, is a transmembrane protein expressed on dendritic cells, subsets of activated CD4+ and CD8+ T cells, and memory B cells that differentiate into plasma cells. At inflammatory sites, PD-L2 is upregulated on synoviocytes, infiltrating macrophages, dendritic cells, and airway epithelial cells. PD-L2, along with B7-H1/PD-L1, binds to T cell PD-1 where it promotes IFN-gamma production and CD40 Ligand upregulation while inhibiting IL-4 production. In addition, PD-L2 binds to RGM-B on macrophages and alveolar epithelial cells, supporting respiratory immune tolerance. In asthma, PD-L2 suppresses IL-5 and IL-13 production, promotes IL-12 production by dendritic cells, and supports allergen-induced airway hyper-responsiveness and mucus production.

33 results for "PD-L2/B7-DC Primary Antibodies" in Products

Catalog #: FAB12241N
Flow
WB, IHC, Block
Catalog #: FAB12241V
Flow
Flow
Flow
Catalog #: BAF1224
WB
Catalog #: BAF1022
WB, IHC
WB, Flow, IHC, Block, CyTOF-ready
Flow
WB, Flow, CyTOF-ready
Block
Catalog #: FAB12241R
Flow
Catalog #: FAB1224R
Flow
Catalog #: FAB12241T
Flow
Catalog #: FAB12241G
Flow
Catalog #: FAB12241S
Flow
Catalog #: FAB1224U
Flow
Catalog #: FAB1224S
Flow
Catalog #: FAB12241U
Flow
Catalog #: FAB1022R
Flow
ELISA
Catalog #: FAB1022T
Flow
ELISA
Catalog #: FAB1022G
Flow
Results Per Page
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