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Osteopontin/OPN: Simple Plex

Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed and is prominent in mineralized tissues. It inhibits bone mineralization and kidney stone formation and promotes inflammation, cell ad­hesion, and migration. Its expression is upregulat­ed during inflammation, obesity, atherosclerosis, cancer, and tissue damage and contributes to the pathophysiology of these conditions. The central region of OPN contains RGD and non-RGD binding sites for multiple integrins. Adjacent to the RGD motif is the sequence SLAYGLR (SVVYGLR in human) which serves as a cryptic binding site for additional integrins: it is masked in full length OPN but is exposed following OPN cleavage by multiple proteases in tumors and sites of tissue injury.

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5 results for "Osteopontin/OPN Simple Plex" in Products

Osteopontin/OPN: Simple Plex

Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed and is prominent in mineralized tissues. It inhibits bone mineralization and kidney stone formation and promotes inflammation, cell ad­hesion, and migration. Its expression is upregulat­ed during inflammation, obesity, atherosclerosis, cancer, and tissue damage and contributes to the pathophysiology of these conditions. The central region of OPN contains RGD and non-RGD binding sites for multiple integrins. Adjacent to the RGD motif is the sequence SLAYGLR (SVVYGLR in human) which serves as a cryptic binding site for additional integrins: it is masked in full length OPN but is exposed following OPN cleavage by multiple proteases in tumors and sites of tissue injury.

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5 results for "Osteopontin/OPN Simple Plex" in Products

Simple Plex Mouse/Rat Osteopontin/OPN assay kit for use on Ella instrument. Contains cartridge, sample diluent SD09, and wash buffer.

Simple Plex Cartridge Kit for quantitation of OPN. Contains cartridge, sample diluent SD13, and wash buffer

Catalog #: 898393
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Control for use with Mouse/Rat Osteopontin/OPN Simple Plex Cartridge Kit

Catalog #: 896959
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Control for use with Human Osteopontin/OPN Simple Plex Cartridge Kit

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