MXRA8/DICAM Products
DICAM, also known as Limitrin and MXRA8, is a transmembrane adhesion protein that is expressed on the endothelium of many tissues. In the vascular system, it is found on pericytes, vascular endothelial cells (EC), and the vessel-contacting feet of astrocytes. It is upregulated on EC by VEGF and functions as a negative regulator of angiogenesis. It inhibits VEGF-induced signaling, cell migration, capillary tube formation, and in vivo angiogenesis, and promotes EC apoptosis. The interaction of DICAM with Integrin alpha V beta 3 enhances cell adhesion and inhibits the differentiation of osteoclasts.
3 results for "MXRA8/DICAM" in Products
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MXRA8/DICAM Products
DICAM, also known as Limitrin and MXRA8, is a transmembrane adhesion protein that is expressed on the endothelium of many tissues. In the vascular system, it is found on pericytes, vascular endothelial cells (EC), and the vessel-contacting feet of astrocytes. It is upregulated on EC by VEGF and functions as a negative regulator of angiogenesis. It inhibits VEGF-induced signaling, cell migration, capillary tube formation, and in vivo angiogenesis, and promotes EC apoptosis. The interaction of DICAM with Integrin alpha V beta 3 enhances cell adhesion and inhibits the differentiation of osteoclasts.
3 results for "MXRA8/DICAM" in Products
Source : | CHO |
Accession # : | Q9BRK3 |
Applications : | Bioactivity |