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28 results for "LAG-3" in Products

LAG-3 Products

LAG-3 (Lymphocyte activation gene-3; CD223) is a transmembrane protein that binds to MHC class II molecules and negatively regulates T cell receptor signaling. It is expressed on activated T cells, NK cells, and plasmacytoid dendritic cells (pDC). LAG-3 limits the expansion of activated T cells and pDC in response to select stimuli. Proteolytic shedding of LAG-3 enables normal T cell activation by removing the negative regulation. Binding of a homodimerized soluble LAG-3/Ig fusion protein to MHC class II molecules induces maturation of immature DC as well as secretion of pro-inflammatory cytokines by cytotoxic CD8+ T cells and NK cells.

Reactivity:
Human
Assay Range:
93.8-6000 pg/mL
Applications:
ELISA
(2)
Reactivity:
Human
Details:
Goat IgG Polyclonal
Applications:
WB, Flow
Detection of LAG-3 antibody in CD3+Human PBMCs antibody by Flow Cytometry.

Biotinylated

Reactivity:
Human
Source:
CHO
Accession #:
P18627.5
Applications:
Bioactivity
Recombinant Human LAG-3 Fc Chimera Avi-tag Protein Binding Activity
(2)
Reactivity:
Human
Source:
NS0
Accession #:
P18627
Applications:
Bioactivity
Recombinant Human LAG-3 Fc Chimera Biotinylated Protein Binding Activity
Reactivity:
Human
Details:
Mouse IgG1 kappa Monoclonal Clone #17B4
Applications:
IHC, WB, Flow, ICC/IF, IP, + 1 More
Novus Antibodies
Reactivity:
Human
Details:
Mouse IgG2A Monoclonal Clone #874525
Applications:
WB, Flow
Novus Antibodies
Reactivity:
Human, Primate
Details:
Mouse IgG1 kappa Monoclonal Clone #L4-PL33
Applications:
IHC, WB, ELISA, Flow, ICC/IF, + 1 More
Novus Antibodies
Reactivity:
Human, Monkey
Details:
Mouse IgG1 Monoclonal Clone #11E3
Applications:
IHC, WB, ELISA, Flow, ICC/IF, + 1 More
Novus Antibodies
Reactivity:
Human
Details:
Mouse IgG2B Monoclonal Clone #OTI8F6
Applications:
IHC, WB, Flow
Novus Antibodies

Recombinant Monoclonal Antibody

Reactivity:
Human
Details:
Human IgG4 Monoclonal
Applications:
ELISA, Flow, Func
Novus Antibodies

Recombinant Monoclonal Antibody

Reactivity:
Human
Details:
Human IgG4 Monoclonal
Applications:
ELISA, Flow, Func
Novus Antibodies

Recombinant Monoclonal Antibody

Reactivity:
Human
Details:
Human IgG4 Monoclonal
Applications:
ELISA, Flow, Func
Novus Antibodies

Recombinant Monoclonal Antibody

Reactivity:
Human
Details:
Human IgG4 Monoclonal
Applications:
ELISA, Flow, Func
Novus Antibodies

Recombinant Monoclonal Antibody

Reactivity:
Human
Details:
Human IgG4 Monoclonal
Applications:
ELISA, Flow, Func
Novus Antibodies

Recombinant Monoclonal Antibody

Reactivity:
Human
Details:
Human IgG4 Monoclonal
Applications:
ELISA, Flow, Func
Novus Antibodies
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