54 results for "Jak3" in Products
Jak3 Products
Jak1, Jak 2, and Jak3 belong to the Janus Kinases family of protein tyrosine kinases that couple to cytokine receptors once activated by their corresponding ligands. Activation of Jak family members occurs via phosphorylation at two adjacent tyrosine residues as well as potentially one or more serine residues. Jaks activate members of the STAT family of transcription factors by phosphorylating critical tyrosine regulatory sites.
Jak1 is required for the activation of STAT1 and STAT2 in ...
Potent JAK inhibitor
| Alternate Names: | Tofacitinib citrate |
| Chemical Name: | (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrile citrate |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #5H2 |
| Applications: | WB, ELISA, ICC/IF, Flow |
![Western Blot: Jak3 Antibody (5H2)BSA Free [NBP2-37737]](https://resources.bio-techne.com/images/products/Jak3-Antibody-5H2-Western-Blot-NBP2-37737-img0001.jpg "Western Blot: Jak3 Antibody (5H2)BSA Free [NBP2-37737]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Applications: | CyTOF-ready, ICC, ICFlow |
EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
| Alternate Names: | Tyrphostin AG 490 |
| Chemical Name: | (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: Jak3 Antibody [NBP2-49629]](https://resources.bio-techne.com/images/products/Jak3-Antibody-Immunohistochemistry-Paraffin-NBP2-49629-img0005.jpg "Immunohistochemistry-Paraffin: Jak3 Antibody [NBP2-49629]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #452524 |
![Western Blot: Jak3 Overexpression Lysate [NBL1-12094]](https://resources.bio-techne.com/images/products/JAK3-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-12094-img0002.jpg "Western Blot: Jak3 Overexpression Lysate [NBL1-12094]")
Potent and selective JAK3 inhibitor
| Chemical Name: | 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malate |
| Purity: | ≥98% (HPLC) |
Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable
| Alternate Names: | JAK inhibitor I |
| Chemical Name: | 2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one |
| Purity: | ≥98% (HPLC) |
Potent and selective JAK2/3 Degrader (PROTAC®)
| Chemical Name: | 4-((4-(1-(3-(Cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-N-(3-(4-(4-(2,6-dioxopiperidin-3-yl)phenyl)piperazin-1-yl)propyl)benzamide |
| Purity: | ≥97% (HPLC) |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: Jak3 Antibody [NBP3-12702]](https://resources.bio-techne.com/images/products/Jak3-Antibody-Western-Blot-NBP3-12702-img0001.jpg "Western Blot: Jak3 Antibody [NBP3-12702]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #1C7 |
| Applications: | IHC, ELISA |
![Immunohistochemistry: Jak3 Antibody (1C7) [NBP3-15196]](https://resources.bio-techne.com/images/products/Jak3-Antibody-1C7-Immunohistochemistry-NBP3-15196-img0001.jpg "Immunohistochemistry: Jak3 Antibody (1C7) [NBP3-15196]")
| Applications: | ELISA |
