7 results for "Inflammasomes Inhibitors Small Molecules and Peptides" in Products
Inflammasomes Inhibitors: Small Molecules and Peptides
A canonical inflammasome consists of a sensor molecule, which binds to caspase 1 via the adaptor protein ASC (apoptosis-associated speck-like protein). The exact composition of the inflammasome is determined by the type of activator. The most common sensor molecules are NOD-like receptors (NLRs); these include the subtypes NLRP1 (NOD-, LRR- and pyrin domain-containing 1), NLRP3, NLRP6, NLRP7, NLRP12, AND NLRC4 (NOD-, LRR- and CARD-containing 4; IPAF). Other sensor molecules include PYHIN, AIM2 ...
Cell-permeable, irreversible caspase inhibitor
| Chemical Name: | Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone |
| Purity: | ≥95% (HPLC) |
Caspase-1 and NLRP3 inflammasome inhibitor
| Chemical Name: | Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate |
| Purity: | ≥98% (HPLC) |
Potent NLRP3 inflammasome inhibitor
| Chemical Name: | 2-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino)-5-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7(4H)-thione |
| Purity: | ≥95% (HPLC) |
Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
| Alternate Names: | CP-456773,MCC 950 |
| Chemical Name: | N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt |
| Purity: | ≥98% (HPLC) |
NLRP3 inhibitor; active in vivo
| Chemical Name: | 4-[[4-Oxo-2-thioxo-3-[[3-(trifluoromethyl)phenyl]methyl]-5-thiazolidinylidene]methyl]benzoic acid |
| Purity: | ≥98% (HPLC) |
NLRP3 inflammasome inhibitor
| Alternate Names: | JC121 |
| Chemical Name: | N-[2-[4-(Aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide |
| Purity: | ≥98% (HPLC) |
NLRP3 inflammasome inhibitor; disrupts inflammasome formation
| Chemical Name: | 3-(Methylsulfonyl)propanenitrile |
| Purity: | ≥98% |
