EBF-3: Proteins and Enzymes

EBF-3 (Early B cell Factor 3; also OE2 and COE3) is a 65 kDa (predicted) member of the COE family of transcription factors. It has limited expression, being identified principally in cerebellar Purkinje cells, olfactory neurons, and differentiating mantle layer neurons. Mouse EBF-3 is 596 amino acids (aa) in length it contains one DNA-binding region with an embedded zinc-finger motif (aa 51-235), a dimerization segment between aa 371-431, and a Pro/Ser-rich transactivation domain (aa 464-555). EBF-3 either homodimerizes, or heterodimerizes with EBF-2 or -1. There are at least two potential splice variants, one that shows a nine aa deletion between aa 252-260, and a second that shows the same deletion coupled to a one aa substitution for aa 521-557. Over aa 399-504, mouse EBF-3 shows more than 99% aa identity to rat and human EBF-3.