Dkk-4 Products
Dickkopf related protein 4 (Dkk-4) is a member of the Dkk protein family of secreted Wnt antagonists. Dkk-1 and Dkk-4 antagonize Wnt/beta-catenin signaling by direct high affinity binding to the Wnt coreceptor LRP5/6 and inhibiting interaction of LRP5/6 with the Wnt-Frizzled complex. Dkk-1 and Dkk-4 also bind the transmembrane proteins Kremen-1 and Kremen-2 with high affinity. Kremen-2 can form a ternary complex with Dkk-1 or Dkk-4 plus LRP5/6 to trigger internalization of the complex and removal of LRP6 from the cell surface. Thus, Dkk-1/4 and Kremens function synergistically to antagonize LRP5/6-mediated Wnt activity.
Products:
103 results for "Dkk-4" in Products
103 results for "Dkk-4" in Products
Dkk-4 Products
Dickkopf related protein 4 (Dkk-4) is a member of the Dkk protein family of secreted Wnt antagonists. Dkk-1 and Dkk-4 antagonize Wnt/beta-catenin signaling by direct high affinity binding to the Wnt coreceptor LRP5/6 and inhibiting interaction of LRP5/6 with the Wnt-Frizzled complex. Dkk-1 and Dkk-4 also bind the transmembrane proteins Kremen-1 and Kremen-2 with high affinity. Kremen-2 can form a ternary complex with Dkk-1 or Dkk-4 plus LRP5/6 to trigger internalization of the complex and removal of LRP6 from the cell surface. Thus, Dkk-1/4 and Kremens function synergistically to antagonize LRP5/6-mediated Wnt activity.
Products:
Contains 4 membranes - each spotted in duplicate with 26 different cell stress antibodies
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Source: | NS0 |
| Accession #: | NP_055235 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Source: | NS0 |
| Accession #: | Q8VEJ3 |
| Applications: | BA, BA |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #185709 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #185709 |
| Applications: | WB, ELISA(Cap), ELISA(Det) |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #185709 |
| Applications: | WB, ELISA(Cap), ELISA(Det) |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #185709 |
| Applications: | WB, ELISA(Cap), ELISA(Det) |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #185709 |
| Applications: | WB, ELISA(Cap), ELISA(Det) |