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Chk2 Products
The Chk2 checkpoint kinase is an integral member of the signaling cascade that controls cell cycle checkpoints. In response to genotoxic insults Chk2 is phosphorylated by ATM or ATM-related kinases. Phosphorylation of Chk2 T68 promotes the formation of Chk2 oligomers. Oligomerization is a critical event in the activation of the Chk2 kinase as it is required for phosphorylation of additional Chk2 residues that lead to full activation and signaling to downstream effectors.
12 results for "Chk2" in Products
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Chk2 Products
The Chk2 checkpoint kinase is an integral member of the signaling cascade that controls cell cycle checkpoints. In response to genotoxic insults Chk2 is phosphorylated by ATM or ATM-related kinases. Phosphorylation of Chk2 T68 promotes the formation of Chk2 oligomers. Oligomerization is a critical event in the activation of the Chk2 kinase as it is required for phosphorylation of additional Chk2 residues that lead to full activation and signaling to downstream effectors.
12 results for "Chk2" in Products
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
WB, ICC
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #1238H |
| Applications : | Immunocytochemistry/Immunofluorescence, Western Blot |
Catalog #:
MAB1358
WB
Recombinant Monoclonal Antibody.
| Clonality : | Monoclonal |
| Host : | Rabbit IgG Clone #2521A |
| Applications : | Western Blot |
Catalog #:
DYC1626-2
ELISA
| Assay Range : | 312 - 20,000 pg/mL |
| Applications : | ELISA |
Catalog #:
5199
Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing
| Chemical Name : | 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride |
| Purity : | ≥98% (HPLC) |
Catalog #:
5140
Potent and selective allosteric inhibitor of Wip1 phosphatase
| Chemical Name : | 5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide |
| Purity : | ≥98% (HPLC) |
Selective Chk2 inhibitor
| Alternate Names : | DDUG |
| Chemical Name : | 2,2'-[Carbonylbis(imino-4,1-phenyleneethylidyne]bishydrazinecarboximidamide) bis(4-methylbenzenesulfonate) |
| Purity : | ≥98% (HPLC) |
Catalog #:
AF1358
WB, KO
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Knockout Validated, Western Blot |
BA
| Source : | Sf 9 (baculovirus) |
| Accession # : | NM_007194 |
| Applications : | Bioactivity |
WB, ICC
| Clonality : | Polyclonal |
| Host : | Rabbit IgG |
| Applications : | Immunocytochemistry/Immunofluorescence, Western Blot |
Catalog #:
4968
Potent Chk2 inhibitor
| Chemical Name : | (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride |
| Purity : | ≥98% (HPLC) |
Catalog #:
MAB22851
WB, IHC
| Clonality : | Monoclonal |
| Host : | Rat IgG2a Clone #235303 |
| Applications : | Immunohistochemistry, Western Blot |
