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Cerberus 1 Products

Cerberus 1, also called DAND4, is a member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus; DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. Cerberus-S, which is generated by proteolysis in Xenopus, is a short version of the molecule and includes the C-terminal cysteine knot domain.

At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in response to Nodal and Shh. Cerberus 1 binds BMP-4 and Nodal and inhibits their activities. Xenopus Cerberus has also been shown to bind Xenopus Wnt-8. These inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation. In chick and Xenopus, Cerberus 1 also regulates, but is not required for embryonic left-right polarization, neurulation, and head and heart induction.

96 results for "Cerberus 1" in Products

Cerberus 1 Products

Cerberus 1, also called DAND4, is a member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus; DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. Cerberus-S, which is generated by proteolysis in Xenopus, is a short version of the molecule and includes the C-terminal cysteine knot domain.

At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in response to Nodal and Shh. Cerberus 1 binds BMP-4 and Nodal and inhibits their activities. Xenopus Cerberus has also been shown to bind Xenopus Wnt-8. These inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation. In chick and Xenopus, Cerberus 1 also regulates, but is not required for embryonic left-right polarization, neurulation, and head and heart induction.

96 results for "Cerberus 1" in Products

Catalog #: BAF1986
WB
Bind
BA
IHC, WB
ELISA, IP, WB
Catalog #: NBP2-89662
ELISA

Recombinant Monoclonal Antibody

Catalog #: NBP2-99620
ELISA
Catalog #: NBP2-99621
ELISA
Catalog #: NBP1-88030PEP
AC
WB, IHC
WB
Catalog #: BAF1075
WB
Catalog #: NBP2-99621PE
ELISA
ELISA
ELISA

Recombinant Monoclonal Antibody

Catalog #: NBP2-99621IR
ELISA
Catalog #: NBP2-99621UV
ELISA
Catalog #: NBP2-99622PE
ELISA, IP, WB
Catalog #: NBP2-89662APC
ELISA

Recombinant Monoclonal Antibody

ELISA

Recombinant Monoclonal Antibody

Catalog #: NBP2-89662IR
ELISA

Recombinant Monoclonal Antibody

ELISA, IP, WB
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