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CDK2 Products
CDK2 (cyclin-dependent kinase 2), a serine/threonine protein kinase, is the catalytic subunit of the heterodimeric cyclin-dependent kinase complex required for G1/S phase transition. The kinase activity of CDK2 is regulated by the association with a cyclin subunit, CDK inhibitors, and its phosphorylation state. The active CDK2/cyclin A complex interacts with the N-terminus of E2F-1 and directs the phosphorylation of E2F-1 and DP-1. The active CDK2/cyclin E complex phosphorylates Rb which disrupts its binding to E2F, allowing E2F activation and transcription of the genes necessary for S-phase entry and progression. Inhibition of the CDK2/cyclin complex can be attributed to its association with p21Waf1/Cip1 and p27Kip1 and the phosphorylation of CDK2 on Thr14 and Tyr15. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Tyr14 and Tyr15.
21 results for "CDK2" in Products
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CDK2 Products
CDK2 (cyclin-dependent kinase 2), a serine/threonine protein kinase, is the catalytic subunit of the heterodimeric cyclin-dependent kinase complex required for G1/S phase transition. The kinase activity of CDK2 is regulated by the association with a cyclin subunit, CDK inhibitors, and its phosphorylation state. The active CDK2/cyclin A complex interacts with the N-terminus of E2F-1 and directs the phosphorylation of E2F-1 and DP-1. The active CDK2/cyclin E complex phosphorylates Rb which disrupts its binding to E2F, allowing E2F activation and transcription of the genes necessary for S-phase entry and progression. Inhibition of the CDK2/cyclin complex can be attributed to its association with p21Waf1/Cip1 and p27Kip1 and the phosphorylation of CDK2 on Thr14 and Tyr15. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Tyr14 and Tyr15.
21 results for "CDK2" in Products
| Clonality : | Polyclonal |
| Host : | Goat IgG |
| Applications : | Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot |
Potent HMG-CoA reductase inhibitor
| Alternate Names : | Mevinolin |
| Chemical Name : | (2S)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl-2-methyl butanoate |
| Purity : | ≥98% (HPLC) |
Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9
| Chemical Name : | 4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine |
| Purity : | ≥99% (HPLC) |
Cdk inhibitor; potently inhibits cdk2 and cdk9
| Alternate Names : | L 86-8275 |
| Chemical Name : | 2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride |
| Purity : | ≥98% (HPLC) |
HMG-CoA reductase inhibitor
| Chemical Name : | (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate |
| Purity : | ≥98% (HPLC) |
Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9
| Alternate Names : | BMS-387032 |
| Chemical Name : | N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide |
| Purity : | ≥99% (HPLC) |
Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
| Alternate Names : | NG 60 |
| Chemical Name : | (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
| Purity : | ≥98% (HPLC) |
Cdk inhibitor; potently inhibits cdk1 and cdk2
| Chemical Name : | (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl) (2,6-difluoro-4-methylphenyl)methanone |
| Purity : | ≥97% (HPLC) |
Potent cdk inhibitor
| Chemical Name : | 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol |
| Purity : | ≥98% (HPLC) |
Potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9
| Alternate Names : | SCH 727965 |
| Chemical Name : | (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol |
| Purity : | ≥98% (HPLC) |
Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
| Alternate Names : | NG 95 |
| Chemical Name : | (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
| Purity : | ≥99% (HPLC) |
Cdk2 and cdk5 inhibitor
| Chemical Name : | 2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol] |
| Purity : | ≥98% (HPLC) |
Cdk inhibitor
| Chemical Name : | (2R)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol |
| Purity : | ≥98% (HPLC) |
Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
| Alternate Names : | NG 97 |
| Chemical Name : | (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
| Purity : | ≥98% (HPLC) |
Cdk1 and cdk2 inhibitor
| Chemical Name : | 6-(Cyclohexylmethoxy)-9H-purin-2-amine |
| Purity : | ≥99% (HPLC) |
Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members
| Chemical Name : | N-[1-[[3-[[(2E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]phenyl]sulfonyl]-4-piperidinyl]-4-[(2,4,6- trichlorobenzoyl)amino]-1H-pyrazole-3-carboxamide |
| Purity : | ≥98% (HPLC) |
Potent and selective cdk inhibitor; orally bioavailable
| Chemical Name : | [4-Amino-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-5-pyrimidinyl](2,3-difluoro-6-methoxyphenyl)methanone |
| Purity : | ≥98% (HPLC) |
Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B
| Chemical Name : | 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide |
| Purity : | ≥99% (HPLC) |
GSK-3β inhibitor; also inhibits cdks
| Chemical Name : | 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one |
| Purity : | ≥98% (HPLC) |
Potent and selective DYRK1A inhibitor
| Chemical Name : | 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole |
| Purity : | ≥98% (HPLC) |
Potent CDK2 inhibitor
| Alternate Names : | AUZ 454 |
| Chemical Name : | N-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea |
| Purity : | ≥98% (HPLC) |
