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CDK2 Products

CDK2 (cyclin-dependent kinase 2), a serine/threonine protein kinase, is the catalytic subunit of the heterodimeric cyclin-dependent kinase complex required for G1/S phase transition. The kinase activity of CDK2 is regulated by the association with a cyclin subunit, CDK inhibitors, and its phosphorylation state. The active CDK2/cyclin A complex interacts with the N-terminus of E2F-1 and directs the phosphorylation of E2F-1 and DP-1. The active CDK2/cyclin E complex phosphorylates Rb which disrupts its binding to E2F, allowing E2F activation and transcription of the genes necessary for S-phase entry and progression. Inhibition of the CDK2/cyclin complex can be attributed to its association with p21Waf1/Cip1 and p27Kip1 and the phosphorylation of CDK2 on Thr14 and Tyr15. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Tyr14 and Tyr15.

21 results for "CDK2" in Products

CDK2 Products

CDK2 (cyclin-dependent kinase 2), a serine/threonine protein kinase, is the catalytic subunit of the heterodimeric cyclin-dependent kinase complex required for G1/S phase transition. The kinase activity of CDK2 is regulated by the association with a cyclin subunit, CDK inhibitors, and its phosphorylation state. The active CDK2/cyclin A complex interacts with the N-terminus of E2F-1 and directs the phosphorylation of E2F-1 and DP-1. The active CDK2/cyclin E complex phosphorylates Rb which disrupts its binding to E2F, allowing E2F activation and transcription of the genes necessary for S-phase entry and progression. Inhibition of the CDK2/cyclin complex can be attributed to its association with p21Waf1/Cip1 and p27Kip1 and the phosphorylation of CDK2 on Thr14 and Tyr15. The activation of the CDK2/cyclin complex requires the phosphorylation of Thr160 and the dephosphorylation of Tyr14 and Tyr15.

21 results for "CDK2" in Products

Potent HMG-CoA reductase inhibitor

Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9

Cdk inhibitor; potently inhibits cdk2 and cdk9

HMG-CoA reductase inhibitor

Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9

Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

Cdk inhibitor; potently inhibits cdk1 and cdk2

Potent cdk inhibitor

Potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9

Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

Cdk2 and cdk5 inhibitor

Cdk inhibitor

Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

Cdk1 and cdk2 inhibitor

Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members

Potent and selective cdk inhibitor; orally bioavailable

Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B

GSK-3β inhibitor; also inhibits cdks

Potent and selective DYRK1A inhibitor

Potent CDK2 inhibitor

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