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Apurinic/Apyrimidinic Endonuclease (APE), also known as redox factor 1 (Ref-1), is a multifunctional enzyme involved in both DNA repair and transcription factor binding. The C-terminal region is responsible for base excision repair activities. This repair activity, however, is suppressed by phosphorylation. The N-terminal region of APE may regulate the DNA binding capabilities of a variety of transcription factors through redox stimulation.