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Angiopoietin-like Protein 4/ANGPTL4 Products

Angiopoietin-like 4 (ANGPTL4), also known as FIAF, FARP, and PGAR, is a 55 kDa glycoprotein secreted by the liver and fat tissue. It contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain which can be proteolytically separated. The coiled coil domain mediates the formation of variable sized disulfide-linked oligomers. This domain directly inhibits lipoprotein lipase (LPL), resulting in increased circulating triglyceride levels. ANGPTL4 circulates in association with HDL lipoproteins. Its expression in adipose tissue is induced by fasting and suppressed by feeding. In hypoxic areas, ANGPTL4 is induced in both vascular endothelial cells and tumor cells. The N-terminal fragment can function as an angiogenesis inhibitor. In contrast, the C-terminal fragment modulates cell adhesion through interactions with heparan sulfate proteoglycans, Integrins alpha 1 and beta 5, Vitronectin, and Fibronectin, thereby promoting keratinocyte migration and wound healing. ANGPTL4 additionally enhances the survival of hematopoietic and mesenchymal stem cells.

26 results for "Angiopoietin-like Protein 4/ANGPTL4" in Products

Angiopoietin-like Protein 4/ANGPTL4 Products

Angiopoietin-like 4 (ANGPTL4), also known as FIAF, FARP, and PGAR, is a 55 kDa glycoprotein secreted by the liver and fat tissue. It contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain which can be proteolytically separated. The coiled coil domain mediates the formation of variable sized disulfide-linked oligomers. This domain directly inhibits lipoprotein lipase (LPL), resulting in increased circulating triglyceride levels. ANGPTL4 circulates in association with HDL lipoproteins. Its expression in adipose tissue is induced by fasting and suppressed by feeding. In hypoxic areas, ANGPTL4 is induced in both vascular endothelial cells and tumor cells. The N-terminal fragment can function as an angiogenesis inhibitor. In contrast, the C-terminal fragment modulates cell adhesion through interactions with heparan sulfate proteoglycans, Integrins alpha 1 and beta 5, Vitronectin, and Fibronectin, thereby promoting keratinocyte migration and wound healing. ANGPTL4 additionally enhances the survival of hematopoietic and mesenchymal stem cells.

26 results for "Angiopoietin-like Protein 4/ANGPTL4" in Products

BA

C-Terminal Fragment

Catalog #: 898432

Control for use with Human Angiopoietin-like Protein 4/ANGPTL4 Simple Plex Cartridge Kit

InhibAct
InhibAct
BA

N-Terminal Fragment

WB, Simple Western
Flow
WB
Catalog #: FAB11305N
Flow
Catalog #: FAB11305S
Flow
Catalog #: FAB11305G
Flow
Catalog #: MAB9797
ELISA
Catalog #: FAB11305V
Flow
Catalog #: FAB11305R
Flow
Catalog #: FAB11305U
Flow
Catalog #: MAB97971
ELISA
Catalog #: FAB11305T
Flow

Simple Plex Human Angiopoietin-like Protein 4/ANGPTL4 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.

InhibAct
BA

Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies

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