alpha-2B Adrenergic R/ADRA2B Products
Alpha-2-adrenergic receptors, including ADRA2B, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C that have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. ADRA2B was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of ADRA2B was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity.
89 results for "alpha-2B Adrenergic R/ADRA2B" in Products
89 results for "alpha-2B Adrenergic R/ADRA2B" in Products
alpha-2B Adrenergic R/ADRA2B Products
Alpha-2-adrenergic receptors, including ADRA2B, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C that have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. ADRA2B was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of ADRA2B was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity.
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | ICC/IF |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #491613 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #491613 |
Applications: | Flow, CyTOF-ready |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #491613 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #491613 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #491613 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #491613 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #491613 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #491613 |
Applications: | Flow |
Reactivity: | Mouse, Rat |
Details: | Mouse IgG1 Monoclonal Clone #5G10 |
Applications: | IHC, WB |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #491613 |
Applications: | Flow, CyTOF-ready |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #491613 |
Applications: | Flow, CyTOF-ready |
Applications: | AC |
Applications: | AC |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #491613 |
Applications: | Flow, CyTOF-ready |
Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
Alternate Names: | d-Medetomidine hydrochloride |
Chemical Name: | 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride |
Purity: | ≥98% |
α1 and α2B antagonist; also MT3 antagonist
Chemical Name: | 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride |
Purity: | ≥99% (HPLC) |
Potent and selective adrenergic α2B antagonist
Chemical Name: | 1-[2-[[[3-(3,5-Dimethyl-4-isoxazolyl)imidazo[1,2-a]pyridin-7-yl]carbonyl]amino]ethyl]-4-(methylamino)pyridinium chloride |
Purity: | ≥98% (HPLC) |
Selective α2 antagonist
Chemical Name: | 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride |
Purity: | ≥98% (HPLC) |
α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
Chemical Name: | 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate |
Purity: | ≥99% (HPLC) |