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alpha-2B Adrenergic R/ADRA2B Products
Alpha-2-adrenergic receptors, including ADRA2B, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C that have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. ADRA2B was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of ADRA2B was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity.
30 results for "alpha-2B Adrenergic R/ADRA2B" in Products
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alpha-2B Adrenergic R/ADRA2B Products
Alpha-2-adrenergic receptors, including ADRA2B, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C that have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. ADRA2B was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of ADRA2B was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity.
30 results for "alpha-2B Adrenergic R/ADRA2B" in Products
Selective α2 antagonist
| Chemical Name : | 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride |
| Purity : | ≥98% (HPLC) |
α2 agonist
| Chemical Name : | 5-(Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride |
| Purity : | ≥99% (HPLC) |
Selective α2 antagonist
| Chemical Name : | 5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride |
| Purity : | ≥99% (HPLC) |
Highly selective α2B antagonist
| Alternate Names : | RS 21361 |
| Chemical Name : | 2-(1-Ethyl-2-indazoyl)methyl-1,4-benzodioxan hydrochloride |
| Purity : | ≥98% (HPLC) |
I1 ligand. Also α2 agonist
| Chemical Name : | 2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate |
| Purity : | ≥98% (HPLC) |
Potent and non-selective β antagonist; also potent α1 antagonist
| Alternate Names : | BM 14190 |
| Chemical Name : | 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol |
| Purity : | ≥98% (HPLC) |
Potent and selective α2 antagonist
| Chemical Name : | 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride |
| Purity : | ≥98% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #491613 |
| Applications : | Flow Cytometry |
Potent, selective α2D antagonist
| Chemical Name : | 2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride |
| Purity : | ≥99% (HPLC) |
Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
| Alternate Names : | d-Medetomidine hydrochloride |
| Chemical Name : | 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride |
| Purity : | ≥98% |
Selective α2 agonist
| Alternate Names : | Azepexole |
| Chemical Name : | 6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride |
| Purity : | ≥99% (HPLC) |
α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
| Chemical Name : | 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate |
| Purity : | ≥99% (HPLC) |
Potent and highly selective α2 agonist
| Chemical Name : | 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride |
| Purity : | ≥99% (HPLC) |
Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
| Chemical Name : | (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate |
| Purity : | ≥98% (HPLC) |
α2 agonist
| Chemical Name : | 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline |
Potent and selective α2 antagonist
| Chemical Name : | (8aR,12aS,13aS)-5,8,8a,9,10,11,12,12a,13,13a-dechydro-3-methoxy-12-(ethylsulfonyl)-6H-isoquino[2,1-g][1,6]naphthyridine hydrochloride |
| Purity : | ≥99% (HPLC) |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #491613 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #491613 |
| Applications : | CyTOF-ready, Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #491613 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #491613 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #491613 |
| Applications : | Flow Cytometry |
| Clonality : | Monoclonal |
| Host : | Mouse IgG1 Clone #491613 |
| Applications : | Flow Cytometry |
α2B antagonist
| Chemical Name : | 2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride |
| Purity : | ≥98% (HPLC) |
α2 agonist. Also I2 selective ligand
| Chemical Name : | [(2,6-Dichlorobenzylidene)amino]guanidine acetate |
| Purity : | ≥98% (HPLC) |
D2-like agonist (D2>D3>D4)
| Chemical Name : | (5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione mesylate |
| Purity : | ≥98% (HPLC) |
