Expert Insights: Pioneering ADC Development and Analysis
Imaged Capillary Electrophoresis (iCE)
The primary advantage of MauriceFlex from the perspective of LC-MS analysis is the sample compatibility. The charge variants of interest are fractionated within an ammonium acetate matrix. This reduces the sample preparation time compared to other charge variant separation techniques such as ion exchange chromatography, where buffer exchange is often required due to the salt content present from the mobile phase.