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TAG degradation technology offers a generalizable strategy to degrade, in principle, any intracellular protein of interest (POI). Its key benefit is that it does not rely on the pre-existence of a ligand for the POI. The broad applicability that it offers makes this a useful strategy for exploration and validation of targets, particularly in the context of new Degrader development programs.

This white paper highlights a full dTAG workflow solution, from custom KI cell lines for a protein of interest, to different dTAG Degraders available for treatment and subsequent quantitative characterization using an automated high throughput western blotting platform, Simple WesternTM.

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