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Shining New Light on Pharmacokinetic Analysis with Simple Western

Summary

Simple Western™ on Peggy Sue™ combines the separation power of cIEF and CE-SDS assays with the sensitive and specific detection of an immunoassay. This combination places Simple Western in a unique position to study the PK properties of therapeutic monoclonal antibodies and their biosimilars. 

In this Application Note, Simple Western Charge and Size assays provided a complete picture of the PK activity of adalimumab in human serum. The Simple Western Charge assay provided the most wealth of information and was able to detect significant changes in the drug profiles over the course of the study, including the detection of unexpected stress-associated acidic peaks.

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