Discontinued Product
2960 has been discontinued.
View all Cav1.x Channel Blockers products.
Product Description
Felodipine is a L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.Product Specifications
Molecular Weight
384.25
Formula
C18H19Cl2NO4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
CAS Number
72509-76-3
PubChem ID
3333
InChI Key
RZTAMFZIAATZDJ-UHFFFAOYSA-N
SMILES
ClC1=C(Cl)C(C2C(C(OC)=O)=C(C)NC(C)=C2C(OCC)=O)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.42 | 100 | |
| Ethanol | 38.42 | 100 |
Preparing Stock Solutions
for Felodipine
The following data is based on the product molecular weight 384.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.60 mL | 13.01 mL | 26.02 mL |
| 5 mM | 0.52 mL | 2.60 mL | 5.20 mL |
| 10 mM | 0.26 mL | 1.30 mL | 2.60 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Furukawa Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 1999 PMID: 10525060
- Furukawa Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+ channel (α1G) expressed in Xenopus oocytes. J.Cardiovasc.Pharmacol. 2005 PMID: 15725949
- Ljung Vascular selectivity of felodipine: experimental pharmacology. J.Cardiovasc.Pharmacol. 1990 PMID: 1693715
Product Specific Notices for Felodipine
For research use only
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