α-Conotoxin PnIA
Tocris Bioscience, part of Bio-Techne | Catalog # 3123
Selective α3β2 nAChR antagonist
Discontinued Product
3123 has been discontinued.
View all Additional Nicotinic Receptor Antagonists products.
Key Product Details
Description
Selective α3β2 nAChR antagonist
Product Description
α-Conotoxin PnIA is a selective antagonist of α3β2 nAChR receptors (IC50 values are 9.56 and 252 nM for α3β2 and α7 receptors respectively).Licensing Information
Sold under license from University of UtahProduct Specifications
Molecular Weight
1622.82
Formula
C65H95N19O22S4
Storage
Desiccate at -20°C
CAS Number
705300-84-1
PubChem ID
73755066
InChI Key
VUVGEYBNLLGGBG-MVPSLEAZSA-N
SMILES
[H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC2=O)C(N)=O)NC1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 5mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Luo Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectivity. Biochemistry 1999 PMID: 10545176
- Everhart Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 2003 PMID: 12734390
- Fainzilber New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptors. Biochemistry 1994 PMID: 8068627
Product Specific Notices for α-Conotoxin PnIA
For research use only
Loading...
Loading...