2-Hydroxypropyl-β-cyclodextrin

Name: 2-Hydroxypropyl- β -cyclodextrin
Brand: Tocris Bioscience
SKU: 0708

Tocris Bioscience a Bio-Techne Brand

Catalog # 0708

Citations (2)

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Key Product Details

Description:	Solubilization agent
Alternative Names:	HBC, Hydroxypropyl-β-cyclodextrin
Molecular Weight:	1400

View Full Technical Details for 2-Hydroxypropyl-β-cyclodextrin

Biological Activity for 2-Hydroxypropyl-β-cyclodextrin

The most widely used modified cyclodextrin, the lipophilic cavity formed by 7 glucose units. Drug solubility in water is greatly enhanced by complexing with HBC.

Technical Data for 2-Hydroxypropyl-β-cyclodextrin

M. Wt	1400
Formula	(C₆H₉O₅)₇(C₃H₇O)n
Storage	Store at RT
CAS Number	128446-35-5
PubChem ID	44134771
InChi Key	BZRWCHBEBFPRGF-UHFFFAOYSA-N
Smiles	O[C@@H]1[C@H]8C(COCC(C)O)O[C@H](O[C@H](C(COCC(C)O)O[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O[C@H](C(COCC(C)O)O[C@H](O[C@@H]5C(O)C(O)[C@H](O[C@@H]6C(O)C(O)[C@H](O[C@H](C(COCC(C)O)O[C@H](O8)[C@H]7O)[C@H]7O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)[C@H]4O)[C@@H]4O)OC3COCC(C)O)[C@H]2O)[C@H]2O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2-Hydroxypropyl-β-cyclodextrin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	140	100

Preparing Stock Solutions for 2-Hydroxypropyl-β-cyclodextrin

The following data is based on the product molecular weight 1400.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.71 mL	3.57 mL	7.14 mL
5 mM	0.14 mL	0.71 mL	1.43 mL
10 mM	0.07 mL	0.36 mL	0.71 mL
50 mM	0.01 mL	0.07 mL	0.14 mL

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Reconstitution Calculator

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References for 2-Hydroxypropyl-β-cyclodextrin

References are publications that support the biological activity of the product.

Frijlink The effects of cyclodextrins on the disposition of intravenously injected drugs in the rat. Pharm.Res. 1991 PMID: 2052529
Pitha Hydroxypropyl-β-cyclodextrin: preparation and characterisation; effects on solubility of drugs. Int.J.Pharmacol.

Citations for 2-Hydroxypropyl-β-cyclodextrin (2)

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Citations are publications that use Bio-Techne products. Selected citations for 2-Hydroxypropyl-β-cyclodextrin include:

Marco et al. (2016) Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour. Nat Commun. 7:12620
PMID: 27646867
Johnson et al. (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Proc Natl Acad Sci U S A. 107:733
PMID: 22554617

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