Chicago Sky Blue 6B

Name: Chicago Sky Blue 6B
Brand: Tocris Bioscience
SKU: 0846
Price: 98 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0846

Citations (1)

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Key Product Details

Description:	Dye used as counterstain in histochemistry; also potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF
Chemical Name:	6,6'-[(3,3-Dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt
Molecular Weight:	992.79

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Biological Activity for Chicago Sky Blue 6B

Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles. Allosterically inhibits macrophage migration inhibitory factor (MIF) (IC₅₀ = 0.81 μM); inhibits MIF proinflammatory activity. Also dye used as counterstain in histochemistry.

Technical Data for Chicago Sky Blue 6B

M. Wt	992.79
Formula	C₃₄H₂₄N₆Na₄O₁₆S₄
Storage	Store at RT
CAS Number	2610-05-1
PubChem ID	102063628
InChi Key	BPHHNXJPFPEJOF-UHFFFAOYSA-J
Smiles	[Na+].[Na+].[Na+].[Na+].COC1=CC(=CC=C1\N=N\C1=C(O)C2=C(C=C1)C(=CC(=C2N)S([O-])(=O)=O)S([O-])(=O)=O)C1=CC(OC)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S([O-])(=O)=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Chicago Sky Blue 6B

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	99.28	100

Preparing Stock Solutions for Chicago Sky Blue 6B

The following data is based on the product molecular weight 992.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.01 mL	5.04 mL	10.07 mL
5 mM	0.20 mL	1.01 mL	2.01 mL
10 mM	0.10 mL	0.50 mL	1.01 mL
50 mM	0.02 mL	0.10 mL	0.20 mL

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References for Chicago Sky Blue 6B

References are publications that support the biological activity of the product.

Bai A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J.Biol.Chem. 2012 PMID: 22782901
Roseth Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transport. J.Neurochem. 1995 PMID: 7790899
Fonnum Inhibitors of amino acid uptake into vesicles. J.Neurochem.

Citations for Chicago Sky Blue 6B (1)

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Citations are publications that use Bio-Techne products. Selected citations for Chicago Sky Blue 6B include:

Bai et al. (2012) A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). J Biol Chem. 287:30653
PMID: 22782901

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