(1R,1'S,3'R/1R,1'R,3'S)-L-054,264
Tocris Bioscience, part of Bio-Techne | Catalog # 2444
Potent and selective sst2 agonist
Discontinued Product
2444 has been discontinued.
View all Somatostatin Receptor Agonists products.
Key Product Details
Description
Potent and selective sst2 agonist
Product Description
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a potent and selective somatostatin sst2 receptor agonist (Ki values are 4, 537, 2480, 3614 and 5017 nM for cloned human sst2, sst1, sst4, sst3 and sst5 receptors respectively).Product Specifications
Molecular Weight
539.71
Formula
C33H41N5O2
Storage
Store at +4°C
Purity
≥96% (HPLC)
Chemical Name
N-[(1R)-2-[[[(1S*,3R*)-3-(Aminomethyl)cyclohexyl]methyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxoethyl]spiro[1H-indene-1,4'-piperidine]-1'-carboxamide
CAS Number
208706-12-1
PubChem ID
9915239
InChI Key
DAMXHAMKVXERLM-FVBCXUTKSA-N
SMILES
NC[C@H]1CCC[C@@H](CNC([C@H](NC(N4CCC5(C(C=CC=C6)=C6C=C5)CC4)=O)CC2=CNC3=C2C=CC=C3)=O)C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.99 | 50 | |
| Ethanol | 53.97 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 539.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.85 mL | 9.26 mL | 18.53 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.85 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Yang Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J.Med.Chem. 1998 PMID: 9632348
Product Specific Notices
For research use only
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