Combretastatin A4
Tocris Bioscience, part of Bio-Techne | Catalog # 1495
Antiangiogenic
Discontinued Product
1495 has been discontinued.
View all Microtubule Binding Compounds products.
Key Product Details
Description
Antiangiogenic
Alternative Names
CRC 87-09,NSC 817373
Product Description
Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo. Inhibits tubulin polymerization.Product Specifications
Molecular Weight
316.35
Formula
C18H20O5
Storage
Desiccate at -20°C
Purity
≥99%
Chemical Name
2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol
CAS Number
117048-59-6
PubChem ID
5351344
InChI Key
HVXBOLULGPECHP-WAYWQWQTSA-N
SMILES
OC1=CC(\C=C/C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.64 | 100 | |
| Ethanol | 31.64 | 100 |
Preparing Stock Solutions
for Combretastatin A4
The following data is based on the product molecular weight 316.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.16 mL | 15.81 mL | 31.61 mL |
| 5 mM | 0.63 mL | 3.16 mL | 6.32 mL |
| 10 mM | 0.32 mL | 1.58 mL | 3.16 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.63 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Griggs Potent anti-metastatic activity of combretastatin-A4. Int.J.Oncol. 2001 PMID: 11562761
- Lin Combretastatin A4-induced differential cytotoxicity and reduced metastatic ability by inhibition of AKT function in human gastric cancer cells. J.Pharmacol.Exp.Ther. 2007 PMID: 17646428
- Dorr Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor. Invest.New Drugs 1996 PMID: 8913833
Product Specific Notices for Combretastatin A4
For research use only
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