MRT 10

Name: MRT 10
Brand: Tocris Bioscience
SKU: 4585

Tocris Bioscience, part of Bio-Techne | Catalog # 4585

COA / SDS

Smoothened (Smo) antagonist

Discontinued Product

4585 has been discontinued. View all Smoothened Receptor Antagonists products.

Key Product Details

Description:	Smoothened (Smo) antagonist
Chemical Name:	N-[[[3-Benzoylamino)phenyl]amino]thioxomethyl]-3,4,5-trimethoxybenzamide
Purity:	≥98%
Molecular Weight:	465.52

View Full Technical Details for MRT 10

Technical Data
Citations

Biological Activity for MRT 10

MRT 10 is a smoothened (Smo) receptor antagonist (IC₅₀ = 0.5 μM in HEK293 cells transiently expressing mouse Smo). Inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells (IC₅₀ = 2.5 μM); acts as an inverse agonist during nontranscriptional Hedgehog pathway activation (IC₅₀ = 2.5 μM in HEK293 cells).

Technical Data for MRT 10

M. Wt	465.52
Formula	C₂₄H₂₃N₃O₅S
Storage	Store at +4°C
Purity	≥98%
CAS Number	330829-30-6
PubChem ID	1139102
InChi Key	KVQVEZQDNHMQJV-UHFFFAOYSA-N
Smiles	O=C(NC(NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2)=S)C1=CC(OC)=C(OC)C(OC)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for MRT 10

References are publications that support the biological activity of the product.

Manetti Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol.Pharmacol. 2010 PMID: 20664000
Solinas Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J.Med.Chem. 2012 PMID: 22268551

MRT 10

Tocris Bioscience, part of Bio-Techne | Catalog # 4585

Key Product Details

Biological Activity for MRT 10

Technical Data for MRT 10

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for MRT 10

Product Documents for MRT 10

COA

Certificate of Analysis

SDS

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