Tenovin-1
Tocris Bioscience, part of Bio-Techne | Catalog # 3365
Protects against MDM2-mediated p53 degradation
Discontinued Product
3365 has been discontinued.
View all p53 Activators products.
Key Product Details
Description
Protects against MDM2-mediated p53 degradation
Product Description
Tenovin-1 is a p53 activator that protects against MDM2-mediated p53 degradation. Elevates levels of p53 and p21CIP/WAF1 and induces expression from an endogenous p53-dependent promoter. Exhibits potent antiproliferative activity in vitro.Product Specifications
Molecular Weight
369.48
Formula
C20H23N3O2S
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide
CAS Number
380315-80-0
PubChem ID
1013376
InChI Key
WOWJIWFCOPZFGV-UHFFFAOYSA-N
SMILES
CC(C)(C)C1=CC=C(C(NC(NC2=CC=C(NC(C)=O)C=C2)=S)=O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.24 | 25 |
Preparing Stock Solutions
for Tenovin-1
The following data is based on the product molecular weight 369.48
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.83 mL | 54.13 mL | 108.26 mL |
| 1.25 mM | 2.17 mL | 10.83 mL | 21.65 mL |
| 2.5 mM | 1.08 mL | 5.41 mL | 10.83 mL |
| 12.5 mM | 0.22 mL | 1.08 mL | 2.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Lain Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell 2008 PMID: 18455128
Product Specific Notices for Tenovin-1
For research use only
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