Zolpidem
Tocris Bioscience, part of Bio-Techne | Catalog # 0655
Benzodiazepine agonist
Discontinued Product
0655 has been discontinued.
View all GABA-A Receptor Benzodiazepines products.
Product Description
Benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors (BZ/ω1 site) and very high intrinsic activity. Ki values are 20, 400 and ≥ 5000 nM for α1-, α2-/α3-, and α5-containing GABAA receptors respectively. Hypnotic that does not induce physical dependence.Product Specifications
Molecular Weight
307.39
Formula
C19H21N3O
Storage
Store at RT
Purity
≥99% (HPLC)
Chemical Name
N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
CAS Number
82626-48-0
PubChem ID
5732
InChI Key
ZAFYATHCZYHLPB-UHFFFAOYSA-N
SMILES
O=C(N(C)C)CC1=C(C3=CC=C(C)C=C3)N=C2N1C=C(C)C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.37 | 50 | |
| Ethanol | 30.74 | 100 |
Preparing Stock Solutions
for Zolpidem
The following data is based on the product molecular weight 307.39
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.25 mL | 16.27 mL | 32.53 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Soderhielm Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors. Biochem.Pharmacol. 2018 PMID: 30121248
- Perrault Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zol. J.Pharmacol.Exp.Ther. 1992 PMID: 1403792
- Crestani Mechanism of action of the hypnotic zol. in vivo. Br.J.Pharmacol. 2000 PMID: 11090095
- Depoortere Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects. J.Pharmacol.Exp.Ther. 1986 PMID: 2871178
- Arbilla High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur.J.Pharmacol. 1986 PMID: 2878820
Product Specific Notices for Zolpidem
For research use only
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