ZK 756326

Name: ZK 756326
Brand: Tocris Bioscience
SKU: 2565

Tocris Bioscience a Bio-Techne Brand

Catalog # 2565

COA / SDS

Discontinued Product

2565 has been discontinued. View all Chemokine Receptor Agonists products.

Key Product Details

Description:	Selective, non-peptide CCR8 agonist
Chemical Name:	2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	429.38

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Biological Activity for ZK 756326

ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC₅₀ values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α_2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.

Technical Data for ZK 756326

M. Wt	429.38
Formula	C₂₁H₂₈N₂O₃.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1780259-94-0
PubChem ID	56972201
InChi Key	MPACCEKWFGWZHS-UHFFFAOYSA-N
Smiles	OCCOCCN(CC3)CCN3CC1=CC=CC(OC2=CC=CC=C2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZK 756326

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	42.94	100

Preparing Stock Solutions for ZK 756326

The following data is based on the product molecular weight 429.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.64 mL	23.29 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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References for ZK 756326

References are publications that support the biological activity of the product.

Haskell Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol.Pharmacol. 2006 PMID: 16221874

Citations for ZK 756326

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