Zinterol hydrochloride

Name: Zinterol hydrochloride
Brand: Tocris Bioscience
SKU: 1051

Catalog # 1051

Citations (4)

COA / SDS

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Key Product Details

Description:	Selective β₂ agonist
Alternative Names:	MJ 9184
Chemical Name:	N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	414.95

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Biological Activity

Zinterol hydrochloride is a potent and selective β₂-adrenoceptor agonist (pK_B values are 8.3 and β₂ and β₁ receptors respectively, as measured in human artery).

Compound Libraries

Zinterol hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	414.95
Formula	C₁₉H₂₆N₂O₄S.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	38241-28-0
PubChem ID	37989
InChi Key	LVNUBJDWJFOMKH-UHFFFAOYSA-N
Smiles	OC1=C(NS(=O)(C)=O)C=C(C(O)CNC(C)(C)CC2=CC=CC=C2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	2.07	5
	DMSO	41.49	100

Preparing Stock Solutions

The following data is based on the product molecular weight 414.95.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.05 mL	24.10 mL
5 mM	0.48 mL	2.41 mL	4.82 mL
10 mM	0.24 mL	1.20 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References

References are publications that support the biological activity of the product.

Hutchinson Agonist effects of zinterol at the mouse and human β3-adrenoceptor. Naunyn Schmiedebergs Arch.Pharmacol. 2006 PMID: 16601951
Arvydas Skeberdis Beta-2 adrenergic activation of L-type Ca²⁺ current in cardiac myocytes. J.Pharmacol.Exp.Ther. 1997 PMID: 9353357
Kauman Four β-adrenoceptor subtypes in the mammalian heart. TiPS 1997 PMID: 9133774

Citations for Zinterol hydrochloride (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Zinterol hydrochloride include:

Huang et al. (2018) ADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to β-blockers in patients with heart failure. Cell Discov. 4:57
PMID: 30374408
Macdougall et al. (2012) Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte. J Mol Cell Cardiol. 52:388
PMID: 21740911
Schutsky et al. (2011) Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci. 31:14172
PMID: 21976502
Eckle et al. (2008) A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Am Coll Cardiol. 118:3301
PMID: 18787641

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