YS-035 hydrochloride

Name: YS-035 hydrochloride
Brand: tocris
SKU: 0416

Catalog # 0416

Datasheet / COA / SDS

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Key Product Details

Description:	Inhibits K⁺ outward/pacemaker current
Chemical Name:	N,N-Bis-(3,4-dimethoxyphenylethyl)-N-methylamine hydrochloride
Molecular Weight:	395.93

View Full Technical Details for YS-035 hydrochloride

Biological Activity

YS-035 hydrochloride is a Ca²⁺ blocker that strikingly prolongs cardiac action potentials by inhibiting pacemaker current and K⁺ outward currents.

Technical Data

M. Wt	395.93
Formula	C₂₁H₂₉NO₄.HCl
Storage	Desiccate at RT
CAS Number	89805-39-0
PubChem ID	56017
InChi Key	GYBONEHHSUABAO-UHFFFAOYSA-N
Smiles	Cl.COC1=CC=C(CCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water		100

Preparing Stock Solutions

The following data is based on the product molecular weight 395.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.63 mL	25.26 mL
5 mM	0.51 mL	2.53 mL	5.05 mL
10 mM	0.25 mL	1.26 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Berger Inhibition of potassium outward currents and pacemaker current in sheep cardiac Purkinje fibres by the vera. derivative YS-035. Naunyn Schmiedebergs Arch.Pharmacol. 1991 PMID: 1775198
Deana Properties of a new calcium ion antagonist on cellular uptake and mitochondrial efflux of calcium ions. Biochem.J. 1984 PMID: 6721841

Citations

Currently there are no citations for YS-035 hydrochloride.

Product Datasheets

COA

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service.