YM 750

Name: YM 750
Brand: Tocris Bioscience
SKU: 3039

Tocris Bioscience a Bio-Techne Brand

Catalog # 3039

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Key Product Details

Description:	ACAT inhibitor
Chemical Name:	N-Cycloheptyl-N-(9H-fluoren-2-ylmethyl)-N'-(2,4,6-trimethylphenyl)urea
Purity:	≥98% (HPLC)
Molecular Weight:	452.63

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Biological Activity for YM 750

YM 750 is an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC₅₀ = 0.18 μM). Exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo.

Licensing Information

Sold with the permission of Astellas Pharma Inc.

Technical Data for YM 750

M. Wt	452.63
Formula	C₃₁H₃₆N₂O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	138046-43-2
PubChem ID	9911716
InChi Key	FMLJREWZCZHGGW-UHFFFAOYSA-N
Smiles	O=C(NC5=C(C)C=C(C)C=C5C)N(C4CCCCCC4)CC3=CC2=C(C=C3)C1=CC=CC=C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YM 750

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.26	100
	ethanol	4.53	10

Preparing Stock Solutions for YM 750

The following data is based on the product molecular weight 452.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.05 mL	22.09 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
10 mM	0.22 mL	1.10 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for YM 750

References are publications that support the biological activity of the product.

Miike Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell dervied foam cells. Life Sci. 2008 PMID: 18037448
Kamiya Bioavailable acyl-CoA: cholesterol acyltransferase inhibitor with anti-peroxidative activity: synthesis and biological activity of novel indolinyl amide and urea derivatives. Chem.Pharm.Bull. 2000 PMID: 10866142
Nagata N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]-(2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem.Pharmacol. 1995 PMID: 7887979

Citations for YM 750

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