Y-26763

Name: Y-26763
Brand: Tocris Bioscience
SKU: 2076
Rating: 5 (1 reviews)

Catalog # 2076 | Tocris Bioscience a Bio-Techne Brand

(1)

COA / SDS

Kir6 (KATP) channel opener

Key Product Details

Description:	K_ir6 (K_ATP) channel opener
Chemical Name:	N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	276.29

View Full Technical Details for Y-26763

Technical Data
Citations / Reviews (1)

Biological Activity for Y-26763

Y-26763 is a K_ir6 (K_ATP) channel opener and active metabolite of Y-27152. Relaxes contracted rat aortic rings (IC₅₀ = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.

Technical Data for Y-26763

M. Wt	276.29
Formula	C₁₄H₁₆N₂O₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	127408-31-5
PubChem ID	121878
InChi Key	IWTCFIIOUXJOOV-OLZOCXBDSA-N
Smiles	CC(=O)N(O)[C@H]1[C@H](O)C(C)(C)OC2=C1C=C(C=C2)C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Y-26763

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH	27.63	100

Preparing Stock Solutions for Y-26763

The following data is based on the product molecular weight 276.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.62 mL	18.10 mL	36.19 mL
5 mM	0.72 mL	3.62 mL	7.24 mL
10 mM	0.36 mL	1.81 mL	3.62 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for Y-26763

References are publications that support the biological activity of the product.

Cosgrove Y-26763: ATP-sensitive K⁺ channel activation and the inhibition of Ins release from human pancreatic β-cells Eur.J.Pharmacol. 2004 PMID: 14975702
Fukunari Y-26763 protects the canine heart from a stunning injury through opening of the K^ATP channels Eur.J.Pharmacol. 1997 PMID: 9128839
Nakajima Y-27152, a long-acting K⁺ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 1992 PMID: 1578381

Citations for Y-26763

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Y-26763 was used to Kir2 channels to understand channel opening.

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: HEK 293

Y-26763 was used to Kir2 inwardly-rectifying potassium channels expressed in HEK293 cell to understand the channel opening.

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