Y-25130 hydrochloride

Name: Y-25130 hydrochloride
Brand: Tocris Bioscience
SKU: 0380
Price: 208 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0380

Citations (2)

COA / SDS

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Key Product Details

Description:	Potent and selective 5-HT₃ antagonist
Chemical Name:	N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	386.28

View Full Technical Details for Y-25130 hydrochloride

Biological Activity for Y-25130 hydrochloride

Y-25130 hydrochloride is a selective and potent 5-HT₃ antagonist (K_i = 2.9 nM).

Technical Data for Y-25130 hydrochloride

M. Wt	386.28
Formula	C₁₇H₂₀ClN₃O₃.HCl
Storage	Desiccate at -20°C
Purity	≥99% (HPLC)
CAS Number	123040-16-4
PubChem ID	115000
InChi Key	DBMKBKPJYAHLQP-UHFFFAOYSA-N
Smiles	Cl.CN1C(=O)COC2=C(C=C(Cl)C=C12)C(=O)NC1CN2CCC1CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Y-25130 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		100
	DMSO	3.86	10

Preparing Stock Solutions for Y-25130 hydrochloride

The following data is based on the product molecular weight 386.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.94 mL	25.89 mL
5 mM	0.52 mL	2.59 mL	5.18 mL
10 mM	0.26 mL	1.29 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for Y-25130 hydrochloride

References are publications that support the biological activity of the product.

Haga The effects of orally administered Y-25130, a selective serotonin₃ receptor antagonist on chemotherapeutic agent-induced emesis. Jpn.J.Pharmacol. 1993 PMID: 8107329
Sato Antagonistic activity of Y-25130 on 5-HT₃ receptors. Jpn.J.Pharmacol. 1992 PMID: 1331590
Fukuda The antiemetic profile of Y-25130, a new selective 5-HT₃ receptor antagonist. Eur.J.Pharmacol. 1991 PMID: 1654255

Citations for Y-25130 hydrochloride (2)

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Citations are publications that use Bio-Techne products. Selected citations for Y-25130 hydrochloride include:

Sándor et al. (2018) Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Front Pharmacol. 9:323
PMID: 29681854
Xiao et al. (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Proc Natl Acad Sci U S A. 4:12
PMID: 18416824

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Product Documents for Y-25130 hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.