Xanthohumol

Tocris Bioscience, part of Bio-Techne | Catalog # 4686

p97 ATPase (VCP) inhibitor
Discontinued Product
4686 has been discontinued. View all Other ER Stress/UPR Inhibitors products.

Key Product Details

Description

p97 ATPase (VCP) inhibitor

View all Other ER Stress/UPR Inhibitors »

Product Description

Xanthohumol is a p97 ATPase (VCP) inhibitor. Binds to the N domain of p97, impairing autophagosome function and maturation. Inhibits proliferation and induces apoptosis in a variety of human cancer cell lines. Also inhibits DGAT in rat liver microsomes (IC50 = 50.3 μM).

Product Specifications

Molecular Weight

354.40

Formula

C21H22O5

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(2E)-1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

CAS Number

6754-58-1

PubChem ID

639665

InChI Key

ORXQGKIUCDPEAJ-YRNVUSSQSA-N

SMILES

OC1=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=CC(O)=C1C/C=C(C)/C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.44 100
Ethanol 35.44 100

Preparing Stock Solutions for Xanthohumol

The following data is based on the product molecular weight 354.40

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.11 mL 28.22 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Xanthohumol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Xanthohumol

For research use only

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