WHI-P 154

Name: WHI-P 154
Brand: Tocris Bioscience
SKU: 3115

Tocris Bioscience, part of Bio-Techne | Catalog # 3115

Citations (1)

COA / SDS

JAK3 kinase inhibitor. Also inhibits EGFR

Discontinued Product

3115 has been discontinued. View all JAK Kinase Inhibitors products.

Key Product Details

Description:	JAK3 kinase inhibitor. Also inhibits EGFR
Chemical Name:	2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
Purity:	≥99% (HPLC)
Molecular Weight:	376.2

View Full Technical Details for WHI-P 154

Technical Data
Citations

Biological Activity for WHI-P 154

WHI-P 154 is a JAK3 inhibitor (IC₅₀ = 1.8 μM) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. Also inhibits other common kinases including EGFR (IC₅₀ = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC₅₀ = 158 μM). Induces differentiation of neural progenitor cells.

Technical Data for WHI-P 154

M. Wt	376.2
Formula	C₁₆H₁₄BrN₃O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	211555-04-3
PubChem ID	3795
InChi Key	CBIAKDAYHRWZCU-UHFFFAOYSA-N
Smiles	OC(C=C3)=C(Br)C=C3NC2=NC=NC1=CC(OC)=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for WHI-P 154

References are publications that support the biological activity of the product.

Kim Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway. Stem Cells. 2010 PMID: 20979137
Sareila Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-α. Int.Immunopharmacol. 2008 PMID: 18068105
Changelian The specificity of JAK3 kinase inhibitors. Blood 2008 PMID: 18094329
Narla 4-(3'-bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells. Clin.Cancer Res. 1998 PMID: 9626456

WHI-P 154

Tocris Bioscience, part of Bio-Techne | Catalog # 3115

Key Product Details

Biological Activity for WHI-P 154

Technical Data for WHI-P 154

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for WHI-P 154

Product Documents for WHI-P 154

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

Stay Connected