WHI-P 154

Name: WHI-P 154
Brand: Tocris Bioscience
SKU: 3115

Tocris Bioscience a Bio-Techne Brand

Catalog # 3115

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Key Product Details

Description:	JAK3 kinase inhibitor. Also inhibits EGFR
Chemical Name:	2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol
Purity:	≥99% (HPLC)
Molecular Weight:	376.2

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Biological Activity for WHI-P 154

WHI-P 154 is a JAK3 inhibitor (IC₅₀ = 1.8 μM) that displays no activity at JAK1 or JAK2. Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro. Also inhibits other common kinases including EGFR (IC₅₀ = 4 nM), Src, Abl, VEGFR, MAPK and PI 3-K and induces apoptosis in human glioblastoma cell lines (IC₅₀ = 158 μM). Induces differentiation of neural progenitor cells.

Technical Data for WHI-P 154

M. Wt	376.2
Formula	C₁₆H₁₄BrN₃O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	211555-04-3
PubChem ID	3795
InChi Key	CBIAKDAYHRWZCU-UHFFFAOYSA-N
Smiles	OC(C=C3)=C(Br)C=C3NC2=NC=NC1=CC(OC)=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WHI-P 154

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.62	100

Preparing Stock Solutions for WHI-P 154

The following data is based on the product molecular weight 376.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.29 mL	26.58 mL
5 mM	0.53 mL	2.66 mL	5.32 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for WHI-P 154

References are publications that support the biological activity of the product.

Kim Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway. Stem Cells. 2010 PMID: 20979137
Sareila Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-α. Int.Immunopharmacol. 2008 PMID: 18068105
Changelian The specificity of JAK3 kinase inhibitors. Blood 2008 PMID: 18094329
Narla 4-(3'-bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells. Clin.Cancer Res. 1998 PMID: 9626456

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WHI-P 154

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Biological Activity for WHI-P 154

Technical Data for WHI-P 154

Solubility for WHI-P 154

Preparing Stock Solutions for WHI-P 154

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for WHI-P 154

Citations for WHI-P 154

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