W-5 hydrochloride

Name: W-5 hydrochloride
Brand: Tocris Bioscience
SKU: 0368

Catalog # 0368

Citations (1)

COA / SDS

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Key Product Details

Description:	Calmodulin antagonist
Chemical Name:	N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride
Molecular Weight:	342.88

View Full Technical Details for W-5 hydrochloride

Biological Activity

W-5 hydrochloride is a calmodulin antagonist (inhibits Ca²⁺-calmodulin dependent PDE with an IC₅₀ of 240 μM).

Technical Data

M. Wt	342.88
Formula	C₁₆H₂₂N₂O₂S.HCl
Storage	Store at RT
CAS Number	61714-25-8
PubChem ID	173829
InChi Key	HOCSVIGHWPLMFC-UHFFFAOYSA-N
Smiles	Cl.NCCCCCCNS(=O)(=O)C1=C2C=CC=CC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	17.14	50
	water	3.43	10

Preparing Stock Solutions

The following data is based on the product molecular weight 342.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.83 mL	29.16 mL	58.33 mL
2.5 mM	1.17 mL	5.83 mL	11.67 mL
5 mM	0.58 mL	2.92 mL	5.83 mL
25 mM	0.12 mL	0.58 mL	1.17 mL

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References

References are publications that support the biological activity of the product.

Hidaka and Tanaka Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 1983 PMID: 6139736
Hidaka Activity-structure relationship of calmodulin antagonists. Naphthalenesulfonamide derivatives. Mol.Pharmacol. 1981 PMID: 7329399
Hidaka N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 1981 PMID: 6945588

Citations for W-5 hydrochloride (1)

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Citations are publications that use Bio-Techne products. Selected citations for W-5 hydrochloride include:

Long et al. (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. PLoS Biol. 284:8726
PMID: 19141616

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