W-5 hydrochloride

Name: W-5 hydrochloride
Brand: tocris
SKU: 0368

Catalog # 0368

Citations (1)

Datasheet / COA / SDS

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	Calmodulin antagonist
Chemical Name:	N-(6-Aminohexyl)-1-naphthalenesulfonamide hydrochloride
Molecular Weight:	342.88

View Full Technical Details for W-5 hydrochloride

Technical Data
Citations (1) / Reviews

Biological Activity

Calmodulin antagonist (inhibits Ca²⁺-calmodulin dependent PDE with an IC₅₀ of 240 μM).

Technical Data

M. Wt	342.88
Formula	C₁₆H₂₂N₂O₂S.HCl
Storage	Store at RT
CAS Number	61714-25-8
PubChem ID	173829
InChi Key	HOCSVIGHWPLMFC-UHFFFAOYSA-N
Smiles	Cl.NCCCCCCNS(=O)(=O)C1=C2C=CC=CC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	17.14	50
	water	3.43	10

Preparing Stock Solutions

The following data is based on the product molecular weight 342.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.83 mL	29.16 mL	58.33 mL
2.5 mM	1.17 mL	5.83 mL	11.67 mL
5 mM	0.58 mL	2.92 mL	5.83 mL
25 mM	0.12 mL	0.58 mL	1.17 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Hidaka Activity-structure relationship of calmodulin antagonists. Naphthalenesulfonamide derivatives. Mol.Pharmacol. 1981 PMID: 7329399
Hidaka N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 1981 PMID: 6945588
Hidaka and Tanaka Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 1983 PMID: 6139736

Citations (1)

Showing 1 - 1 of 1 citation Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for W-5 hydrochloride include:

Long et al. (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. PLoS Biol. 284:8726
PMID: 19141616

There are no citations that match your criteria.

Showing 1 - 1 of 1 citation Showing All

Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

Open modal

W-5 hydrochloride

Order Information

Shipping Information

Key Product Details

Biological Activity

Technical Data

Solubility

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Citations (1)

Product Datasheets

COA

Certificate of Analysis

SDS

Bio-Techne Brands

Stay Connected