VU 0364770

Name: VU 0364770
Brand: Tocris Bioscience
SKU: 4469

Tocris Bioscience, part of Bio-Techne | Catalog # 4469

COA / SDS

Positive allosteric modulator of mGlu4 receptors

Discontinued Product

4469 has been discontinued. View all Group III mGluR Modulators products.

Key Product Details

Description:	Positive allosteric modulator of mGlu₄ receptors
Chemical Name:	N-(3-Chlorophenyl)-2-pyridinecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	232.67

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Technical Data
Citations

Biological Activity for VU 0364770

VU 0364770 is a positive allosteric modulator at mGlu₄ receptors (EC₅₀ = 290 nM in mGlu₄-expressing HEK 293 cells). Reverses haloperidol-induced catalepsy in rats; prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Exhibits affinity for MAO-B and MAO-A (K_i values are 0.72 μM and 8.5 μM respectively). Brain penetrant.

Technical Data for VU 0364770

M. Wt	232.67
Formula	C₁₂H₉ClN₂O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	61350-00-3
PubChem ID	836002
InChi Key	SUYUTNCKIOLMAJ-UHFFFAOYSA-N
Smiles	O=C(C2=NC=CC=C2)NC1=CC=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VU 0364770

References are publications that support the biological activity of the product.

Jones The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J.Pharmacol.Exp.Ther. 2012 PMID: 22088953

VU 0364770

Tocris Bioscience, part of Bio-Techne | Catalog # 4469

Key Product Details

Biological Activity for VU 0364770

Technical Data for VU 0364770

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for VU 0364770

Product Documents for VU 0364770

COA

Certificate of Analysis

SDS

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