V 9302 hydrochloride

Name: V 9302 hydrochloride
Brand: Tocris Bioscience
SKU: 8057

Tocris Bioscience, part of Bio-Techne | Catalog # 8057

COA / SDS

ASCT2 (SLC1A5) inhibitor

Key Product Details

Description:	ASCT2 (SLC1A5) inhibitor
Chemical Name:	(2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoic acid hydrochloride
Purity:	≥97% (HPLC)
Molecular Weight:	575.15

View Full Technical Details for V 9302 hydrochloride

Technical Data
Citations

Biological Activity for V 9302 hydrochloride

V 9302 hydrochloride is an alanine-serine-cysteine transporter 2 (ASCT2, encoded by gene SLC1A5) inhibitor. It inhibits glutamate uptake (IC₅₀ = 9.6 μM in HEK-293 cells). It reduces cancer cell growth and proliferation, also increases cell death and oxidative stress in vitro and in vivo. V 9302 hydrochloride inhibits mTORC1 activity, mitochondrial respiration, proliferation and migration of vascular smooth muscle cells (VSMCs).

Licensing Information

Sold under license from Vanderbilt University

Technical Data for V 9302 hydrochloride

M. Wt	575.15
Formula	C₃₄H₃₈N₂O₄.HCl
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	2416138-42-4
PubChem ID	145710038
InChi Key	LUQMUDMPRZSZTJ-YNMZEGNTSA-N
Smiles	CC1=CC=CC(COC(C=CC=C2)=C2CN(CC[C@H](N)C(O)=O)CC3=C(C=CC=C3)OCC4=CC(C)=CC=C4)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for V 9302 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.76	50 with gentle warming
	ethanol	28.76	50 with gentle warming

Preparing Stock Solutions for V 9302 hydrochloride

The following data is based on the product molecular weight 575.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.48 mL	17.39 mL	34.77 mL
2.5 mM	0.70 mL	3.48 mL	6.95 mL
5 mM	0.35 mL	1.74 mL	3.48 mL
25 mM	0.07 mL	0.35 mL	0.70 mL

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References for V 9302 hydrochloride

References are publications that support the biological activity of the product.

Park V-9302 inhibits proliferation and migration of VSMCs, and reduces neointima formation in mice after carotid artery ligation. Biochem.Biophys.Res.Commun. 2021 PMID: 33965788
Li Inhibitor of glutamine metabolism V9302 promotes ROSinduced autophagic degradation of B7H3 to enhance antitumor immunity. J.Biol.Chem. 2022 PMID: 35189139
Schulte Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat.Med. 2018 PMID: 29334372