Urocortin (rat)

Name: Urocortin (rat)
Brand: Tocris Bioscience
SKU: 1605

Tocris Bioscience, part of Bio-Techne | Catalog # 1605

COA / SDS

Endogenous CRF agonist

Discontinued Product

1605 has been discontinued. View all Non-selective CRF Receptor Agonists products.

Key Product Details

Description:	Endogenous CRF agonist
Molecular Weight:	4707.31

View Full Technical Details for Urocortin (rat)

Technical Data
Citations

Biological Activity for Urocortin (rat)

Urocortin (rat) is an endogenous CRF agonist. K_i values are 13, 1.5 and 0.97 nM for hCRF₁, rCRF₂_α and mCRF₂_β respectively.

Licensing Information

Sold with the permission of the SALK Institute

Technical Data for Urocortin (rat)

M. Wt	4707.31
Formula	C₂₀₆H₃₃₈N₆₂O₆₄
Single Letter Sequence	DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV (Modifications: Val-40 = C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	171543-83-2
PubChem ID	24868227
InChi Key	NLXKHYTZYFPOSU-MLGORUQISA-N
Smiles	[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Urocortin (rat)

References are publications that support the biological activity of the product.

Reul and Holsboer Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr.Opin.Pharmacol. 2002 PMID: 11786305
Skelton The neurobiology of urocortin. Regul.Pept. 2000 PMID: 11033056
Perrin and Vale Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 1999 PMID: 10816663