UPF 648

Tocris Bioscience, part of Bio-Techne | Catalog # 4926

Potent kynurenine 3-monooxygenase (KMO) inhibitor
Discontinued Product
4926 has been discontinued. View all Hydroxylase Inhibitors products.

Key Product Details

Description

Potent kynurenine 3-monooxygenase (KMO) inhibitor

View all Hydroxylase Inhibitors »

Product Description

UPF 648 is a potent kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor (IC50 = 20 nM). Increases kynurenic acid levels, and decreases 3-HK and QUIN levels in cerebrum and liver of neonatal rodents. Neuroprotective in a Drosophila model of Huntington's disease.

Product Specifications

Molecular Weight

259.09

Formula

C11H8Cl2O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

(1S,2S)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic acid

CAS Number

213400-34-1

PubChem ID

9859947

InChI Key

ZBRKMOHDGFGXLN-BQBZGAKWSA-N

SMILES

[H][C@]1([C@@H]([C@](O)=O)C1)C(C2=CC=C(Cl)C(Cl)=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 25.91 100

Preparing Stock Solutions for UPF 648

The following data is based on the product molecular weight 259.09

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.86 mL 19.30 mL 38.60 mL
5 mM 0.77 mL 3.86 mL 7.72 mL
10 mM 0.39 mL 1.93 mL 3.86 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for UPF 648

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for UPF 648

For research use only

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