UNC 2400
Tocris Bioscience, part of Bio-Techne | Catalog # 4905
Negative control of UNC 1999 (Cat. No. 4904)
Discontinued Product
4905 has been discontinued.
View all EZH2 Inhibitor products.
Key Product Details
Description
Negative control of UNC 1999 (Cat. No. 4904)
Product Description
UNC 2400 is a negative control of UNC 1999. Exhibits 1000-fold lower potency than active analog (IC50 values are 62 and >200 μM for EZH1 and EZH2, respectively).Active Analog also available.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary on the SGC website.Product Specifications
Molecular Weight
597.79
Formula
C35H47N7O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[(1,2-Dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]-N-methyl-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide
CAS Number
1433200-49-7
PubChem ID
91691116
InChI Key
IFSQHIRDVVFJSQ-UHFFFAOYSA-N
SMILES
CC(C)N1CCN(C2=NC=C(C3=CC(N(C(C)C)N=C4)=C4C(C(N(C)CC5=C(CCC)C=C(C)N(C)C5=O)=O)=C3)C=C2)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 100 | ||
| DMSO | 100 |
Preparing Stock Solutions
for UNC 2400
The following data is based on the product molecular weight 597.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.67 mL | 8.36 mL | 16.73 mL |
| 5 mM | 0.33 mL | 1.67 mL | 3.35 mL |
| 10 mM | 0.17 mL | 0.84 mL | 1.67 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xu Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood 2015 PMID: 25395428
- Konze An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS Chem.Biol. 2013 PMID: 23614352
Product Specific Notices for UNC 2400
For research use only
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