UK 59811 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6179
CaVAb blocker
Discontinued Product
6179 has been discontinued.
View all Non-selective Cav Blockers products.
Product Description
UK 59811 hydrochloride is a blocks CaVAb, a site-directed mutant of bacterial NaVAb with full voltage-dependent Ca2+ channel function (IC50 = 194 nM).Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
517.84
Formula
C22H29BrN2O5.HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
3-Ethyl 5-methyl 4-(2-bromophenyl)-2-((2-(dimethylamino)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
CAS Number
2250025-89-7
PubChem ID
134812832
InChI Key
JZOQTVYILXBAMQ-UHFFFAOYSA-N
SMILES
CCOC(C1=C(NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Br)COCCN(C)C)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 10.36 | 20 | |
| DMSO | 51.78 | 100 |
Preparing Stock Solutions
for UK 59811 hydrochloride
The following data is based on the product molecular weight 517.84
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.93 mL | 9.66 mL | 19.31 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.93 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Tang Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs. Nature 2016 PMID: 27556947
Product Specific Notices for UK 59811 hydrochloride
For research use only
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