U 18666A

Name: U 18666A
Brand: Tocris Bioscience
SKU: 1638
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1638

(1)

COA / SDS

Inhibitor of Hedgehog (Hh) signaling. Also inhibits cholesterol synthesis

Discontinued Product

1638 has been discontinued. View all Hedgehog Signaling Inhibitors products.

Key Product Details

Description:	Inhibitor of Hedgehog (Hh) signaling. Also inhibits cholesterol synthesis
Chemical Name:	(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
Molecular Weight:	424.07

View Full Technical Details for U 18666A

Technical Data
Citations / Reviews (1)

Biological Activity for U 18666A

U 18666A is an inhibitor of cholesterol synthesis and cellular transport, and weak inhibitor of hedgehog (Hh) signaling. Reduces serum sterol levels in rats in vivo.

Technical Data for U 18666A

M. Wt	424.07
Formula	C₂₅H₄₁NO₂.HCl
Storage	Desiccate at RT
CAS Number	3039-71-2
PubChem ID	92722
InChi Key	KXNPVXPOPUZYGB-IOVMHBDKSA-N
Smiles	[H][C@@]23CC=C1C[C@@H](OCCN(CC)CC)CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for U 18666A

References are publications that support the biological activity of the product.

Incardona Cyclopamine inhibition of sonic hedgehog signal transduction is not mediated through effects on cholesterol transport. Dev.Biol. 2000 PMID: 10926779
Liscum and Faust The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-β-[2-(diethylamino)ethoxy]androst-5-en-17-one. J.Biol.Chem. 1989 PMID: 2745416
Cenedella Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Biochem.Pharmacol. 1980 PMID: 6159896

U 18666A

Tocris Bioscience, part of Bio-Techne | Catalog # 1638

Key Product Details

Biological Activity for U 18666A

Technical Data for U 18666A

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for U 18666A

Product Documents for U 18666A

COA

Certificate of Analysis

SDS

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