Tyrphostin B44, (+) enantiomer

Tocris Bioscience, part of Bio-Techne | Catalog # 0579

EGFR-kinase inhibitor
Discontinued Product
0579 has been discontinued. View all EGF Receptor Inhibitors products.

Key Product Details

Description

EGFR-kinase inhibitor

View all EGF Receptor Inhibitors »

Product Description

Tyrphostin B44, (+) enantiomer is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.86 μM). Slightly less active than the (-) enantiomer.

(-)-enantiomer also available.

Product Specifications

Molecular Weight

308.34

Formula

C18H16N2O3

Storage

Desiccate at +4°C

Chemical Name

(S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide

CAS Number

133550-37-5

PubChem ID

5328769

InChI Key

UMGQVUWXNOJOSJ-DGGAMASNSA-N

SMILES

OC1=C(O)C=CC(\C=C(C(N[C@@H](C)C2=CC=CC=C2)=O)/C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.25 30

Preparing Stock Solutions for Tyrphostin B44, (+) enantiomer

The following data is based on the product molecular weight 308.34

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.3 mM 10.81 mL 54.05 mL 108.11 mL
1.5 mM 2.16 mL 10.81 mL 21.62 mL
3 mM 1.08 mL 5.41 mL 10.81 mL
15 mM 0.22 mL 1.08 mL 2.16 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Tyrphostin B44, (+) enantiomer

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Tyrphostin B44, (+) enantiomer

For research use only

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