Tyrphostin B44, (+) enantiomer

Name: Tyrphostin B44, (+) enantiomer
Brand: tocris
SKU: 0579

Catalog # 0579

Datasheet / COA / SDS

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$35 to United States

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Key Product Details

Description:	EGFR-kinase inhibitor
Chemical Name:	(S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide
Molecular Weight:	308.34

View Full Technical Details for Tyrphostin B44, (+) enantiomer

Biological Activity

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC₅₀ = 0.86 μM). Slightly less active than the (-) enantiomer.

(-)-enantiomer also available.

Technical Data

M. Wt	308.34
Formula	C₁₈H₁₆N₂O₃
Storage	Desiccate at +4°C
CAS Number	133550-37-5
PubChem ID	5328769
InChi Key	UMGQVUWXNOJOSJ-DGGAMASNSA-N
Smiles	OC1=C(O)C=CC(\C=C(C(N[C@@H](C)C2=CC=CC=C2)=O)/C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.25	30

Preparing Stock Solutions

The following data is based on the product molecular weight 308.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	10.81 mL	54.05 mL	108.11 mL
1.5 mM	2.16 mL	10.81 mL	21.62 mL
3 mM	1.08 mL	5.41 mL	10.81 mL
15 mM	0.22 mL	1.08 mL	2.16 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Gazit Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 1991 PMID: 1676428