Trifluorothymidine

Name: Trifluorothymidine
Brand: Tocris Bioscience
SKU: 4460
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4460

(1)

COA / SDS

Thymidylate synthetase inhibitor

Discontinued Product

4460 has been discontinued. View all Thymidylate Synthetase Inhibitor products.

Key Product Details

Description:	Thymidylate synthetase inhibitor
Chemical Name:	α,α,α-Trifluorothymidine
Purity:	≥98% (HPLC)
Molecular Weight:	296.2

View Full Technical Details for Trifluorothymidine

Technical Data
Citations / Reviews (1)

Biological Activity for Trifluorothymidine

Trifluorothymidine is a nucleoside analog; inhibitor of thymidylate synthase. Incorporation of the triphosphate form into DNA induces DNA fragmentation. Exhibits antitumor activity.

Compound Libraries for Trifluorothymidine

Trifluorothymidine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Trifluorothymidine

M. Wt	296.2
Formula	C₁₀H₁₁F₃N₂O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	70-00-8
PubChem ID	6708818
InChi Key	VSQQQLOSPVPRAZ-GFCOJPQKSA-N
Smiles	O=C1C(C(F)(F)F)=CN(C2O[C@H](CO)[C@@H](O)C2)C(N1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Trifluorothymidine

References are publications that support the biological activity of the product.

Emura Potentiation of the antitumor activity of α, α, α-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo. Int.J.Oncol. 2005 PMID: 16010427
Yu Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 2015 PMID: 25658371
Okayama Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J.Pharmacol.Exp.Ther. 2012 PMID: 22076553