(±)-trans-ACPD

Name: (±)- trans -ACPD
Brand: Tocris Bioscience
SKU: 0187
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0187

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Citations (35)

COA / SDS

Group I and II mGlu agonist

Key Product Details

Description:	Group I and II mGlu agonist
Chemical Name:	(±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid
Purity:	≥99% (HPLC)
Molecular Weight:	173.17

View Full Technical Details for (±)-trans-ACPD

Technical Data
Citations / Reviews (1)

Biological Activity for (±)-trans-ACPD

(±)-trans-ACPD is an equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD. Selective agonist for metabotropic glutamate receptors; active at both group I and group II mGlu receptors (EC₅₀ values are 2, 15, 23 and ~800 μM at mGluR₂, mGluR₁, mGluR₅ and mGluR₄ respectively).

(1S,3R)-ACPD and cis-ACPD also available.

Technical Data for (±)-trans-ACPD

M. Wt	173.17
Formula	C₇H₁₁NO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	67684-64-4
PubChem ID	23789032
InChi Key	DXLSPTHQGVGVTN-NAAZMWONSA-N
Smiles	[H][C@@]1(CC[C@@](N)(C1)C(O)=O)C(O)=O.[H][C@]1(CC[C@](N)(C1)C(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (±)-trans-ACPD

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		5 with gentle warming
	1eq. NaOH	8.66	50

Preparing Stock Solutions for (±)-trans-ACPD

The following data is based on the product molecular weight 173.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	11.55 mL	57.75 mL	115.49 mL
2.5 mM	2.31 mL	11.55 mL	23.10 mL
5 mM	1.15 mL	5.77 mL	11.55 mL
25 mM	0.23 mL	1.15 mL	2.31 mL

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Reconstitution Calculator

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References for (±)-trans-ACPD

References are publications that support the biological activity of the product.

Pin and Duvoisin The metabotropic glutamate receptors: structure and functions. Neuropharmacology 1995 PMID: 7623957
Knopfel Metabotropic glutamate receptors: novel targets for drug development. J.Med.Chem. 1995 PMID: 7738999
Nakanishi Molecular diversity of glutamate receptors and implications for brain functions. Science 1992 PMID: 1329206
Conti Synthesis and pharmacology of 3-hydroxy-&#916²-isoxazoline-cyclopentance analogues of glutamic acid Farmaco 2002 PMID: 12484537