trans-4-Hydroxycrotonic acid

Name: trans -4-Hydroxycrotonic acid
Brand: tocris
SKU: 0538

Catalog # 0538

Datasheet / COA / SDS

Discontinued Product

0538 has been discontinued. View all Additional GABA Compounds products.

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Bio-Techne Corporation

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Key Product Details

Description:	GHB receptor ligand
Chemical Name:	trans-4-Hydroxy-2-butenoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	102.09

View Full Technical Details for trans-4-Hydroxycrotonic acid

Technical Data
Citations / Reviews

Biological Activity

Binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself. May be an endogenous ligand.

Technical Data

M. Wt	102.09
Formula	C₄H₆O₃
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	24587-49-3
PubChem ID	6155526
InChi Key	RMQJECWPWQIIPW-OWOJBTEDSA-N
Smiles	OC\C=C\C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.21	100

Preparing Stock Solutions

The following data is based on the product molecular weight 102.09.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	9.80 mL	48.98 mL	97.95 mL
5 mM	1.96 mL	9.80 mL	19.59 mL
10 mM	0.98 mL	4.90 mL	9.80 mL
50 mM	0.20 mL	0.98 mL	1.96 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Bourguignon Analogues of γ-hydroxybutyric acid. Synthesis and binding studies. J.Med.Chem. 1988 PMID: 3361576
Hechler Gamma hydroxybutyrate ligands posses antiDArgic and neuroleptic-like activities. J.Pharmacol.Exp.Ther. 1993 PMID: 8095552
Vayer Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain. Biochem.Pharmacol. 1985 PMID: 4015683