Tin protoporphyrin IX dichloride

Name: Tin protoporphyrin IX dichloride
Brand: tocris
SKU: 0747

Catalog # 0747

Citations (3)

Datasheet / COA / SDS

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Key Product Details

Description:

Heme oxygenase inhibitor

View Full Technical Details for Tin protoporphyrin IX dichloride

Biological Activity

A potent inhibitor of heme oxygenase. Prevents hyperbilirubinemia in neonates.

Technical Data

M. Wt	750.25
Formula	C₃₄H₃₂Cl₂N₄O₄Sn
Storage	Store at RT
CAS Number	14325-05-4
PubChem ID	3000478
InChi Key	ZUQBMBXSEXXKTO-UHFFFAOYSA-L
Smiles	C=CC1=C(/C=C3\N=C(/C=C(N5[Sn](Cl)6Cl)/C(C)=C(CCC(O)=O)/C5=C4)C(C=C)=C3C)N6C(/C=C2/C(C)=C(CCC(O)=O)C/4=N2)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	18.76	25
	DMSO	3.75	5

Preparing Stock Solutions

The following data is based on the product molecular weight 750.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	5.33 mL	26.66 mL	53.32 mL
1.25 mM	1.07 mL	5.33 mL	10.66 mL
2.5 mM	0.53 mL	2.67 mL	5.33 mL
12.5 mM	0.11 mL	0.53 mL	1.07 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Drummond and Kappas Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of haem oxidation. Proc.Natl.Acad.Sci.U.S.A. 1981 PMID: 6947237
Grundemar and Ny Pitfalls using metalloporphyrins in carbon monoxide research. TiPS 1997 PMID: 9226997

Showing 1-3 of 3 citations

Citations (3)

Citations are publications that use Bio-techne products. Selected citations for Tin protoporphyrin IX dichloride include:

Duann et al. (2019) Data on characterization of metalloporphyrin-mediated HO-1 and DAF induction in rat glomeruli and podocytes. Data Brief. 22:279
PMID: 30591946
Ye et al. (2013) Astaxanthin protects against MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis. BMC Neurosci. 13:156
PMID: 23272707
Guimarães et al. (2012) Mitochondrial uncouplers inhibit hepatic stellate cell activation. BMC Gastroenterol. 12:68
PMID: 22686625

Tin protoporphyrin IX dichloride

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Biological Activity

Technical Data

Solubility

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Reconstitution Calculator

References

Citations (3)

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COA

Certificate of Analysis

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